Abstract
Aim: This study investigated the effect of complex formation between sultamicillin tosylate (ST), hydroxypropyl-β cyclodextrin (HP-βCD)and L-arginine (ARG). Materials & methods: The kneading method was used to prepare the complexes, which were then characterized using SEM, DSC, FT-IR, HPLC, saturation solubilityand dissolution studies. The complexes' antibacterial activity against MRSA (ATCC®-43300TM) was evaluated using ZOI and MIC. Results: Solubility was enhanced in the binary and ternary complexes compared with ST (p<0.001). MIC and ZOI showed that both complexes have increased antibacterial activity compared with ST (p<0.001) against MRSA. Conclusion: As a result, the inclusion complex of ST with HP-βCD and ARG can be used to improve the physicochemical properties of ST while also improving antibacterial efficacy against MRSA infections.
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