Abstract
The red dye, amaranth (the trisodium salt of 1-(4-sulpho-1-naphthylazo)-2-naphthol-3,6-disulphonic acid; FD & C Red No. 2; 94% pure), was administered by stomach tube to female Osborne-Mendel rats at dose levels of 0 (control), 7·5, 15, 30, 100 or 200 mg/kg/day during days 0–19 of pregnancy. No adverse clinical signs were observed in any dams. One litter was aborted at the highest dose level. The number of live foetuses per litter was dose-related. At dose levels of 7·5–100 mg/kg, all deaths were classed as early deaths, but at 200 mg/kg there were late deaths and a greater number of early deaths, indicating either systemic effects or foetotoxicity of the compound. The numbers of litters with one or more and two or more resorptions and the number of litters totally resorbed increased with increasing doses of amaranth. No effect was seen in the average weight of the foetuses. No gross terata appeared and neither skeletal nor soft-tissue abnormalities were seen in the experimental animals. There was no sex-related foetal effect.
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