Abstract
Chondroitin sulfate (CS), derived from cartilage tissues, is an important type of biomacromolecule. In this paper, the terahertz time-domain spectroscopy (THz-TDS) was investigated as a potential method for content detection of CS. With the increase of the CS content, the THz absorption coefficients of the CS/polyethylene mixed samples linearly increase. The refractive indices of the mixed samples also increase when the CS content increases. The extinction coefficient of CS demonstrates the THz frequency dependence to be approximately the power of 1.4, which can be explained by the effects of CS granular solids on THz scattering.
Highlights
Articular cartilage (AC) is a transparent connective tissue covering the articular connection surface
The THz signal of empty sample holder was used as reference signal
The results demonstrate that the experimental absorption coefficient curves are in good agreement with the theoretical curves
Summary
Articular cartilage (AC) is a transparent connective tissue covering the articular connection surface. As a kind of important biomacromolecules, CS has many important pharmacological and clinical applications [4] It can decrease the blood lipids level and has a certain effect on preventing and treating cardiovascular diseases, so it is mainly used in clinical treatment of coronary heart disease, rheumatism, arthritis, nephritis etc [5, 6]. It can be used for adjuvant therapy of hearing impairment caused by streptomycin and hepatitis [7]. Conventional measurement technologies include chromatography [8], photometry [9], as well as infrared [10] and Raman spectroscopy [11]
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