Abstract
The aim of this study was to measure effective cortico-cortical connectivity in Multiple sclerosis (MS) patients by TMS-evoked potential (TEP) latencies evoked by transcranial magnetic stimulation (TMS) of the hand area of the primary motor cortex of one hemisphere and recording of TEPs at the homologue site in the non-stimulated contralateral hemisphere. Both interhemispheric directions were tested. Interhemispheric latencies of the two main reproducible TEPs [1], the positive component at 60 ms and the negative component at 100 ms (P60 and N100, respectively), were expected to be significantly prolonged in MS compared to healthy volunteers.
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