Abstract
In vitro studies by Wiemann et al. (1999, 2001) have shown cultured CO2/H+ sensitive neurons from the ventrolateral medulla oblongata of newborn rats to enhance their bioelectric activity upon intracellular acidification induced by selective inhibition of the Na+/H+ exchanger type 3 (NHE-3). Recently, Kiwull- Schône et al. (2001) demonstrated the presence of NHE-3 mRNA in the adult rabbit brainstem, and likewise found NHE-3 immunoreactive neurons in brain-stem areas, which have prevalence for central chemosensitivity. The same study revealed that NHE-3 inhibition by the brain-permeant substance S8218 (Aventis Pharma) also significantly modified the central respiratory CO2-response of brain-stem in vivo. KeywordsObstructive Sleep ApneaPhrenic NerveIntracellular AcidificationBioelectric ActivityThreshold PaC0These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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