Abstract
Abstract Changes in the relative abundances of c–myc mRNA have been related to changes in other parameters of differentiation (histochemical, clonogenic) during the course of the differentiation of HL60 cells to monocytes/ macrophages or to granulocytes. Induction of differentiation to monocytes /macrophages was marked by a rapid rale of appearance of committed cells (80 to 90% in 24 hours) and a concomitant rapid loss ofc–niyc mRNA. Induction of granulocytic differentiation resulted in a much slower rate of appearance of committed cells (50% in 48 hours), and a much faster rate of loss of c–/mr mRNA (tenfold in 1 hour). These data are consistent with there being a direct link between down–regulation of the expression of c–myc and the onset of proliferation arrest and monocytic differentiation, but show there is no such association of c–myc mRNA abundance and proliferation or differentiation during the maturation of HL60 granulocytes.
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