Abstract
Polymorphonuclear neutrophils are thought to play a critical role in the pathogenesis of respiratory conditions in diseases such as chronic obstructive pulmonary disease (COPD), adult respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis. In these diseases, the recruitment and activation of neutrophils is known to contribute to observed dysfunctional symptoms, which include increased airway reactivity, presence of pulmonary fibrosis and mucus hypersecretion. These symptoms are exacerbated by increases in pulmonary cytokines, including tumor necrosis factor-alpha (TNF-) and cytokine-induced neutrophil chemoattractants (CINC-1 and CINC-3).
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