Abstract
Magnetic resonance relaxation times of most tissues are expected to depend on temperature, which can impact findings in postmortem magnetic resonance imaging or when using magnetic resonance imaging for relaxation-based thermometry. The purpose of this study was to investigate the exact temperature dependency of the relaxation times T(1), T(2), T(2) *, and the magnetization transfer ratio in different structures of the human brain. To prevent fixation and autolysis effects, this study was performed with fresh postmortem brain tissues. Following autopsy, coronal brain slices from five deceased subjects were subjected to relaxometry at 3T in a temperature range between 4°C and 37°C. Heating of the tissue was achieved by flushing the vacuum packed brain slices with water at a predefined temperature. T1 showed a linear dependency on temperature with the highest temperature coefficient in the cortex (17.4 ms/°C) and the lowest in the white matter (3.4 ms/°C). T(2) did not depend on temperature. T(2) * and magnetization transfer ratio scaled with temperature only in deep gray matter. The temperature coefficient for T(1) is higher than expected from previous reports and varies across brain structures. The coefficients obtained in this study can serve as reference for thermometry or for correcting quantitative postmortem magnetic resonance imaging.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
