Abstract
Dear editor, Telomeres are the physical ends of eukaryotic chromosomes, and their structures are essential to maintain genome stability and limit cell proliferation (). Normally, the replication of telomeric DNA is done by a molecule called telomerase, which is an enzyme that is inactive in the vast majority of somatic cells. Therefore, every time our cells go into mitosis, we lose pieces of the telomeres (). When telomeres become severely short (as a natural consequence of aging or due genotoxic [...]
Highlights
The authors who identified this gene reported a genetic interaction between Telomere Attrition and p53 Response 1 (TAPR1) and TERT, ACD, and TP53
We noticed a trend of co-occurrence between mutations in TAPR1 with TERT, ACD, and TP53 in The Cancer Genome Atlas (TCGA) cancers
Taking into account only the results with statistical significance, we found that TAPR1 is more expressed in tumors (HNSC, LIHC, LUAD, PRAD, READ, and SKCM) with p53 mutations
Summary
We show the somatic alteration landscape of TAPR1 across TCGA cancers (Figure 1A). Genetic alterations in TAPR1 are not common (especially mutations) and are absent in 10 out of 33 types of cancer. Alterations in TAPR1 do not change the overall and disease-free survival of patients (data not shown). The authors who identified this gene reported a genetic interaction between TAPR1 and TERT (telomerase protein subunit), ACD (or TPP1, a protein involved in recruiting telomerase), and TP53.
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