Abstract
Biomedical Journal of Scientific & Technical Research (BJSTR) is a multidisciplinary, scholarly Open Access publisher focused on Genetic, Biomedical and Remedial missions in relation with Technical Knowledge as well. Our BJSTR maintains a scrupulous, methodical, fair peer review System. Besides, quality control is riveted in each step of the publication process.
Highlights
Nucleic acids (DNA/RNA) are delivered to cancer cells to either initiate the expression of harmful proteins that are able to kill them or to inhibit the function of crucial proteins in the cells
The nucleic acids encapsulated within nanoparticles are safeguarded against possible degradation in the circulatory system
Nontarget delivery of nucleic acids is still a major concern with cationic nanoparticles and enhancing targeting efficacy is a key problem for cancer gene therapy [4]
Summary
Nucleic acids (DNA/RNA) are delivered to cancer cells (a method known as transfection) to either initiate the expression of harmful proteins that are able to kill them or to inhibit the function of crucial proteins in the cells. Nontarget delivery of nucleic acids is still a major concern with cationic nanoparticles and enhancing targeting efficacy is a key problem for cancer gene therapy [4]. To overcome these issues recently various groups have developed functionalized polymers through the conjugation of targeting ligands (aptamer, peptide, lipids, small molecule and antibody/antibody fragment etc.) for delivering DNA/ RNA to tumour sites effectively. Polymeric nanoparticle platforms are characterized by their unique physicochemical structures, including polymeric micelle, solid polymeric nanoparticles, polymer conjugate, polymer some, dendrimer, polyplex, and polymer-lipid hybrid system This mini review will cover the natural and synthetic polymers used to make nanoparticles for the delivery of genes to tumor sites (Table 1)
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