Abstract
The Indian house mouse populations, in addition to extreme polymorphism for nuclear genes encoding for various isozymes and mitochondrial DNA also show a high level of variation for the TCRVΒ17 gene. RFLP analysis has revealed six variant forms of the gene which are classified on the basis of size of the restriction fragment. These forms are not present in the laboratory inbred strains. The new alleles are present at different frequencies in nine Indian localities. Gene expression study showed that all the alleles are functional and expressed, though at varying levels. No case of clonal deletion was observed in these animals. Variable expression levels of theVΒ17 gene in these natural populations of mice might be under the control of the MHC haplotype.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
