Abstract
Cysteine metabolism in rat hepatocytes is highly regulated in response to the dietary levels of protein and sulfur amino acids1, 2. Primary cultures of rat hepatocytes might be useful for studies of the regulation of cysteine metabolism, including taurine production. However, conventional monolayer cultures are known to lose many of the differentiated functions of liver cells. Recently, it has been reported that hepatocytes cultured as spheroids (multicellular aggregates with well-defined cellular morphology) maintain certain highly differentiated functions of liver parenchymal cells such as secretion of albumin7, 5.
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