Abstract
Oral administration of a 3% beta alanine solution in the drinking water was as effective in increasing urinary taurine excretion and decreasing tissue taurine levels in rats as subcutaneous or intraperitoneal administration. Beta alanine was more effective in reducing tissue taurine levels in rats and guinea pigs than in mice. Other inhibitors of taurine transport were compared with beta alanine for their ability to reduce tissue taurine levels. Taurocyamine, the guanidino analogue of taurine, was less effective in rats than beta alanine in reducing taurine levels in gastrocnemius but more effective in reducing brain taurine levels, whereas the homologue of beta alanine, GABA, was relatively ineffective in either mice or rats.
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