Abstract
Taurine is the most abundant amino acid in the body and an important osmolyte, antioxidant, chaperone and immunomodulator. Resent study showed that taurine transporter (TauT) knockout induces fibrosis and unspecific inflammation in the liver at an age of 15 – 17 months. In the present study, we analyzed effects of taurine depletion in TauT-KO mice on ammonia metabolism, oxidative stress and senescence in livers from 3 or 12 months old mice.
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