Abstract
Unhealthy diet, in particular high-fat diet (HFD) intake, can cause the development of several metabolic disorders, including obesity, hyperlipidemia, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS). These popular metabolic diseases reduce the quality of life, and induce premature death worldwide. Evidence is accumulating that the gut microbiota is inextricably associated with HFD-induced metabolic disorders, and dietary intervention of gut microbiota is an effective therapeutic strategy for these metabolic dysfunctions. Polysaccharides are polymeric carbohydrate macromolecules and sources of fermentable dietary fiber that exhibit biological activities in the prevention and treatment of HFD-induced metabolic diseases. Of note, natural polysaccharides are among the most potent modulators of the gut microbiota composition. However, the prebiotics-like effects of polysaccharides in treating HFD-induced metabolic diseases remain elusive. In this review, we introduce the critical role of gut microbiota human health and HFD-induced metabolic disorders. Importantly, we review current knowledge about the role of natural polysaccharides in improving HFD-induced metabolic diseases by regulating gut microbiota.
Highlights
Diet can affect multiple aspects of human health, and high-fat diet (HFD) contributes to the epidemics of obesity and obesity-associated chronic metabolic diseases, such as diabetes, hyperlipidemia, hypertension, non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS; Li et al, 2016)
We introduce the critical role of gut microbiota human health and HFD-induced metabolic disorders
Natural polysaccharides derived from Raphanus sativus display antiobesity property in HDF-fed mice, and by reversing HFD-induced intestinal microbial dysbiosis via reducing the ratio of Firmicutes/Bacteroidetes, and increasing Verrucomicrobia (Do et al, 2021)
Summary
Diet can affect multiple aspects of human health, and high-fat diet (HFD) contributes to the epidemics of obesity and obesity-associated chronic metabolic diseases, such as diabetes, hyperlipidemia, hypertension, non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS; Li et al, 2016). Dictyophora indusiata polysaccharides (DIP) shows anti-obesity effect in HFD-fed mice by reversing HFD-induced gut microbiota dysbiosis, notably by decreasing the ratio of bacteria, Firmicutes/Bacteroidetes (Kanwal et al, 2020). Natural polysaccharides derived from Raphanus sativus display antiobesity property in HDF-fed mice, and by reversing HFD-induced intestinal microbial dysbiosis via reducing the ratio of Firmicutes/Bacteroidetes, and increasing Verrucomicrobia (Do et al, 2021).
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