Abstract
Ethanolic extracts of mycelia from Aspergillus niger (strain N402) grown in liquid media were observed to have haemolytic activity on bovine erythrocytes. This haemolytic activity decreased significantly during the time of growth (1–3 days). Moreover, when A. niger was grown on carbon-deprived medium, the efficiency of this haemolytic activity in the ethanolic extracts was much lower than when grown in carbon-enriched medium, and became almost undetectable after 3 days of growth in carbon-deprived medium. The lipid composition of these ethanolic extracts was analysed by liquid chromatography–electrospray ionisation tandem mass spectrometry. This haemolytic activity can be mainly linked to the relative levels of the molar ratios of the unsaturated fatty acids and lysophosphatidylcholines.
Highlights
Filamentous fungi of the genus Aspergillus comprise more than 200 very common and widespread species, including Aspergillus niger [1]
A. niger N402 mycelia grown in liquid minimal medium with glucose or without it were not haemolytic, which suggested that this biological activity was not linked to the presence of water-soluble proteins or other polar compounds
These ethanolic extracts that were evaluated for their haemolytic activity were obtained from mycelia grown in liquid minimal medium for 24 h or 72 h with (+C)
Summary
Filamentous fungi of the genus Aspergillus comprise more than 200 very common and widespread species, including Aspergillus niger [1]. Members of this genus have important roles in natural ecosystems and in industry, where they are used for the production of numerous enzymes, organic acids, and secondary metabolites. Aspergillus niger is a saprophyte that is commonly isolated from soil, dead leaves, and other decaying plant matter [2]. It reproduces asexually through spores, which can be found almost everywhere. Important products of A. niger are generally recognised as safe by the United States Food and Drug Administration
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