Abstract
Up-regulated monocarboxylate transporters (MCTs) serve as potential targets for the development of novel therapeutic strategies against some cancer cells. Besides being an efficient substrate to some MCTs, the role of alpha-cyano-4-hydroxycinnamic acid (CHCA) as a vector of nanoparticles for cancer cells was not yet evaluated. This aim of this study was to demonstrate the role of CHCA as a vector of liposomes targeting cancer cells that overexpress MCT-1. Also, the antioxidant character of CHCA against induced stress oxidative in cancer cell lines was tested. The authors showed that 50 μM of CHCA led to a significantly enhanced liposome uptake in the MCF-7 and U-87 MG cancer cell lines. Moreover, CHCA decreased MCF-7 cell death from oxidative stress induced by reactive oxygen species generated in situ in a clinical modality known as Photodynamic Therapy. These findings are a proof-of-concept of the role of CHCA as a vector of nanoparticles for targeted cancer therapy. The concept can be explored to develop novel drug delivery systems to target cancer cells of up-regulated MCT-1. Moreover, CHCA-based therapies to avoid oxidative stress can give rise to novel medical treatments.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
