Abstract
We previously developed TANTIGEN, a comprehensive web-based database cataloging more than 1,000 T cell epitopes and HLA ligands from 292 tumor antigens. TANTIGEN 2.0 is significantly expanded the number and coverage of immune response targets (T cell epitopes and HLA ligands) of previously cataloged tumor antigens. We expanded the number of cataloged tumor antigens to more than 4,000 and have added their reported targets of immune responses. We also included neoantigens, a new class of tumor antigens generated through mutations that results in a new amino acid sequence in tumor antigens. TANTIGEN 2.0 contains validated TCR sequences specific for cognate T cell epitopes. Gene expression information was extracted from tumor antigen gene/mRNA/protein expression information in major human cancers provided by Human Pathology Atlas. TANTIGEN 2.0 provides a rich data resource for tumor-associated epitope and neoepitope discovery studies. It is freely available at http://projects.met-hilab.org/tadb.
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