Abstract
Oxidative stress and inflammation have been demonstrated to be involved in the onset and promotion of diabetic nephropathy (DN).Tanshinone IIA (Tan) possesses both antioxidant and anti-inflammatory properties. Here, the aim of the present study was to explore whether Tan could attenuate renal damage in the rats with streptozotocin (STZ)-induced diabetes and its potential mechanisms. Tan was gavaged to STZ-induced diabetic rats at the dose of 10mg/kg once a day for 12 weeks. Tan treatment significantly attenuated albuminuria and renal histopathology in diabetic rats. Besides, Tan treatment also effectively inhibited oxidative stress and inflammatory reaction in the kidneys of diabetic rats. Our study provided evidence that the protective effect of Tan on diabetes-induced renal injury is associated with inhibition of oxidative stress and inflammation. Tan may be a potential candidate for the treatment of DN.
Highlights
Diabetic nephropathy (DN) prevalence is increasing with the expanding size of the diabetes population around the world
The ratio of the kidney weight to body weight (KWI) in diabetic nephropathy (DN) rats received Tanshinone IIA (Tan) treatment was lower compared with DN group and vehicle group (P < 0.05)
These data suggested that Tan could potentially protect the kidneys in diabetic rats, which was independent of blood glucose decrease
Summary
Diabetic nephropathy (DN) prevalence is increasing with the expanding size of the diabetes population around the world. It was reported that one-third of patients with DM develop DN [1]. DN has become leading cause of chronic kidney disease (CKD) in the developed world. The existing treatment for DN are mainly focusing on glycaemic, lipid and blood pressure control, and lifestyle changes [2]. Despite of those therapeutic approach, nearly 50% patients with DN unavoidably processed to the end stage renal disease (ESRD) in the United States [3], which brought along the physical pains for the patients, and lead to heavy social and economic burden. It is urgent to explore the mechanisms and the novel treatments for DN [4, 5]
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