Abstract
Cyclosporin is widely used for the treatment of psoriasis and atopic dermatitis. Tacrolimus is also effective in psoriasis. 1 Abu-Elmagd K Van Thiel D Jegasothy BV et al. FK506: a new therapeutic agent for severe recalcitrant psoriasis.. Transplant Proc. 1991; 23: 3322-3324 PubMed Google Scholar Both drugs have systemic side-effects, including nephrotoxicity. 1 Abu-Elmagd K Van Thiel D Jegasothy BV et al. FK506: a new therapeutic agent for severe recalcitrant psoriasis.. Transplant Proc. 1991; 23: 3322-3324 PubMed Google Scholar With topical formulations of tacrolimus to avoid systemic side-effects, twice-daily applications of ointment containing 0·3, 1, or 3 mg/g were effective in atopic dermatitis. 2 Nakagawa H Etoh T Ishibashi Y et al. Tacrolimus ointment for atopic dermatitis.. Lancet. 1994; 344: 883 Abstract PubMed Scopus (222) Google Scholar Multicentre trials in Japan suggest that 1 mg/g is the optimum concentration for atopic dermatitis. There still remains, however, concern about systemic side-effects due to percutaneous absorption.
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