Abstract
Neuroblastoma is a primary malignancy mainly occurring in children. We have reported polymorphisms of several N6-methyladenosine (m6A) RNA modification related gene contributed to neuroblastoma risk in previous studies. YTHDF2 is involved in cancer progression as a recognizer of m6A. Here, we estimated the association between YTHDF2 gene rs3738067 A>G polymorphism and neuroblastoma susceptibility in 898 neuroblastoma patients and 1734 healthy individuals from China. We found that the rs3738067 A>G could decrease neuroblastoma risk [AG vs. AA: adjusted odds ratio (OR)=0.76, 95% confidence interval (CI)=0.64-0.90, P=0.002; AG/GG vs. AA: adjusted OR=0.81, 95% CI=0.69-0.95, P=0.011). Besides, the rs3738067 AG/GG genotype was related to reduced neuroblastoma risk for children aged 18 months and under, boys, patients with tumors originating from retroperitoneal, patients at clinical stage IV, and cases at clinical stages III plus IV. Importantly, false-positive report probability analysis proved the merit attention of the significant results. The expression quantitative trait locus analysis results revealed that rs3738067 is of great significance for the expression of YTHDF2.
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