Abstract
The systemic regulation of uterine growth during pregnancy has been examined by measuring changes in the nonpregnant uterine horn (NPH) of unilaterally pregnant mice. The wet weight, amounts of protein and DNA and the RNA:DNA ratio in the NPH were determined. The RNA:DNA ratio and the amount of protein in the NPH decline after implantation to minima on Days 7 and 8 of pregnancy, respectively; they then increase steadily to maximum values about the time of parturition. Growth of the NPH up to Day 16 of pregnancy is not influenced by the number of live fetuses in the pregnant uterine horn. When mice are ovariectomized (OVX) on Day 5 and gestation is maintained by giving 1.0 mg progesterone (P) and 10 ng estradiol-l7β (E2) daily, the changes observed in the NPH between Days 5–16 are similar to those seen in intact mice, whereas when OVX mice receive 1.0 mg P and 60 ng E2 daily there is little change in the NPH. It is concluded that the systemic regulation of uterine growth in intact mice during pregnancy cannot be accounted for simply by changes in the levels of circulating P and E2, but also involves a delayed increase in uterine sensitivity to P + E2.
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