Systemic recommendations on the promotion of HPV vaccinations based on international social marketing campaigns.

Human Papillomavirus and Vaccination

To investigate the epidemiology of human papillomavirus (HPV) infection in Malian women, for whom cervical cancer is the most common cancer and the second most common cause of cancer-related mortality. Pilot study of 202 women aged 15-65 to determine the prevalence rate of high-risk HPV infection among unscreened Malian women. Information on risk factors was collected through a standardized, structured interview and clinical examination. High-risk (HR) HPV DNA was detected using signal amplification methods (hybrid capture II). High-risk HPV DNA was detected in 12% of unscreened women, while visual inspection after application of acetic acid and Lugol's iodine (VIA/VILI) identified suspicious abnormalities in 2.5% of unscreened women. Histopathological evaluation of VIA/VILI-positive biopsies revealed no evidence of cervical intraepithelial neoplasia or cervical cancer. The majority of infections occurred among women in the 15-24 year old range. Compared to women who were married or widowed, single women were 3.5 times more likely to be infected with HR HPV. The prevalence of infection with cancer causing types of HPV in this study was 12%. These prevalence estimates are consistent with what has been reported previously for other West African countries.

Human Papillomavirus (Cervical Cancer) Vaccine Update

Racial Disparity in the Prevalence of Cervical Cancer

The incidence and mortality of cervical cancer in young women of reproductive ages have recently increased, which is a serious issue worldwide. This chapter will focus on the prevention of cervical cancer with HPV testing and vaccination. It is recognized that strategies for preventing cervical cancer consist of two major steps: preventing infection of oncogenic human papillomavirus (HPV)-16 and HPV-18 by HPV vaccination and secondary prevention by screening using HPV testing and/or cytology. Current cervical cancer screening strategies using cytology combined with HPV testing have been successfully introduced, with shifting from cytology alone to cytology plus HPV cotesting and now to a new paradigm in which HPV testing alone may become a primary screening tool. HPV vaccination is a “primary prevention” tool, and both the bivalent and quadrivalent HPV vaccines have excellent safety and efficacy profiles. Recently, a 9-valent vaccine, targeted against HPV-6, HPV-11, HPV-16, HPV-18, HPV-31, HPV-33, HPV-45, HPV-52, and HPV-58, has been developed, which may possibly protect against over 80% of invasive cervical cancers. Further evidence on the 9-valent HPV vaccine should be accumulated worldwide, and its application is expected as a new strategy. Finally, the WHO recognizes the prevention of cervical cancer and other HPV-related diseases as global public health problems and strongly recommends the HPV vaccination programs. Both HPV vaccination and cancer screening tests are indispensable for cervical cancer prevention. The complete eradication of this malignant disease in the world will be realized in the near future by the further development and widespread application of these two strategies.

Global strategy to eliminate cervical cancer as a public health problem: are we on track?

Reassessing the Epidemiology of Human Papillomavirus Infection: Back to Basics

Since cervical cancer can be prevented and controlled through human papillomavirus (HPV) vaccination, it is important to train health care providers and provide them with appropriate knowledge. This study aimed to understand the level of HPV related knowledge among medical students and correlates in Southwest China in order to address any potential gap in their knowledge base. We conducted a cross-sectional survey among medical students in six selected universities across Southwest China based on a pretested questionnaire regarding HPV infection, cervical cancer, and HPV vaccines. We successfully surveyed 1, 878 medical students, of whom 32.1% were males and 67.9% were females. Their mean age was 20.8 (standard deviation: 1.3) years. 91.8% of them were ethnic Han Chinese, and 43.8% were students in clinical medicine. While 76.5% had heard of HPV only 48.8% knew that the prevention of cervical cancer was possible through HPV vaccination. Only 42.9% of the male and 49.2% of the female students correctly answered over 10 out of 22 questions on HPV related knowledge. Female students appeared to know more about HPV and HPV vaccination (OR: 1.39; 95% CI: 1.11-1.75). In addition, the student knowledge improved with the grade (p<0.001). University courses were the most selected source of knowledge about HPV vaccination (66.4%). 83.6% of males and 91.4% of females were willing to have more HPV related education by experts (p<0.001). Only 10.1% of the students acknowledged that people had asked for their advice regarding HPV vaccination. Our survey indicates that medical students from Southwest China have poor knowledge of HPV and HPV vaccination, but are willing to receive more relevant information. Targeted education should be incorporated into school courses to inform these future health care providers and ensure success of programs for cervical cancer control and prevention.

Impact of the human papillomavirus vaccine in low-resource settings

Cervical cancer continues to be a significant global challenge as it is the fourth major cause of mortality among women. Cervical cancer is primarily caused by repeated human papilloma virus (HPV) infections. Although the incidence and death of cervical cancer have declined in high-income nations, the disease still places a heavy burden on low- and middle-income countries. HPV-16Cervical cancer continues to be a significant global challenge as it is the fourth major cause of mortality among women. Cervical cancer is primarily caused by repeated human papilloma virus (HPV) infections. Although the incidence and death of cervical cancer have declined in high-income nations, the disease still places a heavy burden on low- and middle-income countries. HPV-16 is responsible for 50% while HPV-18 is responsible for 10% of cervical cancer cases. The introduction of HPV vaccines is limited in developing areas with greater need, despite the fact that they offer a potential alternative for disease control. The purpose of this research is to review the available information about types and importance of HPV vaccine and methods in promoting it for cervical cancer prevention. Three HPV vaccines for prevention of cervical cancer are available including a quadrivalent vaccine that protects against 4 HPV types, and the second is a bivalent vaccine that protects against 2 high-risk oncogenic HPV types and third is a 9-valent vaccine. All three vaccines provide comparable coverage. Preventative vaccinations against the virus, given to women before HPV infection, have proven to be efficient and have the potential to reduce the incidence of cervical cancer. Thus, it is advised to immunize girls aged 9-14 years. The development of the HPV vaccine has made primary cervical cancer prevention possible. Health promotion and education can potentially contribute to increasing the awareness of community regarding cervical cancer prevention and can lead to better utilization of HPV vaccine.is responsible for 50% while HPV-18 is responsible for 10% of cervical cancer cases. The introduction of HPV vaccines is limited in developing areas with greater need, despite the fact that they offer a potential alternative for disease control. The purpose of this research is to review the available information about types and importance of HPV vaccine and methods in promoting it for cervical cancer prevention. Three HPV vaccines for prevention of cervical cancer are available including a quadrivalent vaccine that protects against 4 HPV types, and the second is a bivalent vaccine that protects against 2 high-risk oncogenic HPV types and third is a 9-valent vaccine. All three vaccines provide comparable coverage. Preventative vaccinations against the virus, given to women before HPV infection, have proven to be efficient and have the potential to reduce the incidence of cervical cancer. Thus, it is advised to immunize girls aged 9-14 years. The development of the HPV vaccine has made primary cervical cancer prevention possible. Health promotion and education can potentially contribute to increasing the awareness of community regarding cervical cancer prevention and can lead to better utilization of HPV vaccine.

Objective The cognition of cervical cancer, Human Papillomavirus (HPV) and HPV vaccine among females from Shenzhen communities was studied, which provided a reference for prevention and treatment of cervical cancer. Methods The multi-stage sampling method was adopted to select 350 females from 10 communities. The questionnaire survey was conducted for understanding the awareness of cervical cancer, HPV and HPV vaccine related knowledge. Results Among 350 copies of questionnaires, 326 copies were actually effective with an effective rate of 93.14%.The awareness rates of HPV, HPV vaccine, cervical cancer etiology, high-risk HPV (main inducing cervical cancer), how to prevent cervical cancer, route of HPV infection and high-risk factors of HPV spreading were 47.24%(154/326), 30.06%(98/326), 48.47%(158/326), 20.6%(67/326), 21.8%(71/326), 21.2%(69/326). The awareness was significantly higher in the females who were in the age of 31-40 years old, with more than 30 thousand income, with college education or above degree, civil servants or office clerks (P<0.05). Conclusions The females from communities have some knowledge about the relationship between cervical cancer and HPV, but lack comprehensive understanding of prevention and treatment of cervical cancer. Especially we need to enhance the diverse health knowledge spread in females who are young, with low-education background, with low income and labors or farmers, improving the awareness rate of prevention and treatment for cervical lesions. Key words: Cervical lesions; Human papillomavirus (HPV); HPV vaccine; Awareness rate; Health education

Background. The age-standardized cervical cancer incidence rate in the Tomsk region in 2021 was consistently higher than the average for the Russian Federation (21.2 / 100,000 versus 13.6 / 100,000 women). Primary prevention of cervical cancer is best achieved by human papillomavirus (HPV) vaccination of girls. Aim. To evaluate HPV vaccine efficacy for the prevention of cervical cancer in the Tomsk region within the framework of implementation of two regional programs: “Prevention of gynecological cancer and rehabilitation of women diagnosed with gynecological cancer in 2008–2010” and “Urgent measures to improve cancer care for the population of the Tomsk region in 2011–2013”. Material and methods. We studied the tolerability and efficacy of HPV vaccination for the prevention of HPV-associated cervical cancer in 439 vaccinated girls aged 9–26 years during a follow-up time of 14-years. Results. The assessment of a 14-year follow-up study of the impact of HPV vaccination on HPV-associated cervical lesions has shown that HPV vaccine is safe and 100 % effective. Conclusion. Further prospects for primary prevention of cervical cancer before the introduction of vaccines against HPV infection in the national immunization schedule indicates the feasibility and real clinical effectiveness of the introduction of regional and regional programs with the development of a mathematical model for optimizing financial costs for primary prevention of cervical cancer, taking into account demographic parameters and socio-economic damage from cervical cancer in the study area.

Acceptability of human papilloma virus vaccination among primary school girls in Minakulu sub-county, northern Uganda.

Vaccinating Adolescents—New Evidence of Challenges and Opportunities

Cervical cancer is a leading cause of morbidity and mortality in women worldwide. The availability of prophylactic vaccines for high-risk types of human papillomavirus (HPV) infection represents an important advancement in the prevention of cervical cancer. In Jordan, the availability of the HPV vaccination is restricted to individuals who are willing to pay. The aim of the current study was to evaluate the willingness and attitude of female university students in health schools/faculties in Jordan to get HPV vaccination and their knowledge about the virus. A self-administered online questionnaire was distributed in October 2021, which comprised 27 items to evaluate HPV knowledge, history of HPV vaccination, intentions to get the HPV vaccine, and the reason(s) behind vaccine refusal for those who rejected vaccination. The study sample comprised 836 participants: medical students (39.7%), pharmacy students (26.0%), dental students (21.2%), and nursing students (13.2%). Only 524 participants had heard of HPV prior to the study (62.7%), of which 48.7% knew about the availability of HPV vaccines. The lowest level of HPV knowledge was observed among nursing students. Only 19/524 students reported a history of HPV vaccination (3.6%). The overall willingness to receive HPV vaccination if provided freely was 75.0%, while only 16.0% were willing to pay for the vaccine. The most common reason for HPV vaccine rejection was the perceived low risk to get HPV infection. Significantly higher intentions to get HPV vaccination were found among older participants and medical students. The embrace of vaccine conspiracy beliefs was associated with a significantly less willingness to get the HPV vaccination (p < 0.001). Dependence on the internet/social media as the source of HPV knowledge was associated with a significantly lower intention to get HPV vaccination (p = 0.002). The coverage of the HPV vaccination among female university students in health schools in Jordan appeared extremely low; however, three-fourths of the students who had heard of HPV were willing to receive the HPV vaccination if provided freely. Complacency appeared as a major factor for HPV vaccine rejection. Increasing the levels of knowledge and awareness of HPV infection and its association with cervical cancer through reliable sources is recommended. This can be helpful for the individual benefit of the students besides the potentially positive role they can play in community education. Countering vaccine conspiracy beliefs with proper education and awareness programs can be helpful to appraise the role of HPV vaccines in cancer prevention.