Abstract
Purpose: Metabolic syndrome is a risk factor for osteoarthritis (OA), which suggests metabolic regulation of OA pathology. Western diet feeding of mice has been shown to result in systemic reprogramming of monocytes to become hyperreactive, which was dependent on IL-1β. Even though we previously showed that IL-1β is not important for the development of pathology in collagenase-induced OA development (CiOA), this might be different in a CiOA model where monocytes are metabolically rewired. Our lab previously showed that Western Diet feeding increased ectopic bone formation and enhanced synovial activation without altering lining thickness during development of CiOA, but it remained unknown if these changes were caused by IL-1β driven monocyte alteration or alternatively by local oxidation of LDL.
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