Abstract
Coronary angiography allows a direct evaluation of coronary anatomy. The aim of the present investigation was to search for correlations between the magnitude of coronary artery disease, as assessed by angiography, and a number of systemic parameters. A group of 116 patients (80 male, 36 female) with coronary heart disease diagnosed by angiography, aged 62.0±10.5 years, was the subject of an observational study. Correlation and linear regression analysis using coronary artery disease burden (CADB - sum of the percentage of the luminal stenosis encountered in all the lesions of the coronary arterial trees) as dependent variable, and age, sex, plasma calcium, phosphorus, magnesium, glucose, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, estimated glomerular filtration rate and body mass index as independent variables, were carried out. Significant correlation values versus CADB were seen with age (r 0.19, p 0.04), uric acid (r 0.18, p 0.048) and fasting plasma glucose (r 0.33, p<0.001). Linear regression analysis, yielding a global significance level of 0.002, showed a significant value for glucose (p 0.018) and for sex (0.008). In conclusion, among several systemic parameters studied, plasma glucose was found to be correlated to coronary artery atherosclerosis lesions.
Highlights
Coronary artery disease is a frequent and important disease, for which a number of risk factors have been identified
Significant correlation values versus coronary artery disease burden (CADB) were seen with age (r 0.19, p 0.04), uric acid (r 0.18, p 0.048) and fasting plasma glucose (r 0.33, p,0.001)
Standard coronary angiography was used as a means to estimate coronary artery disease burden, by adding the values corresponding to each lesion found [2]
Summary
Coronary artery disease is a frequent and important disease, for which a number of risk factors have been identified. The study of the magnitude of coronary artery disease in patients with confirmed disease may be of help in elucidating mechanisms underlying growth of coronary atherosclerosis lesions. This type of evidence may be of use, to be added to evidence on the risk of having the disease, notwithstanding the fact that some of the factors that increase risk may increase growth. A decrease in renal function was noted to be associated to coronary artery disease [2]
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