Abstract
Varicose vein disease (VVD) undoubtedly has its genetic and epigenetic constituents. However, there is still an enigma around them. In order to observe systemic effects, we decided to shift paradigm at this time and to study possible gene expression differences that may reflect genetically predisposing determinants, between normal venous tissue samples from both conditionally healthy patients and those with VVD, and analyzed nonvaricose (!) vein segments in both cases.
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