Abstract
Under the Atherton–Todd reaction conditions, the stereochemistry on the reaction of H-phosphinates with different nucleophiles (e.g., amines, alcohols, phenols) was investigated. All reactions took place stereospecifically with inversion of configurations at the phosphorus centers. The reaction might proceed via a phosphoryl chloride intermediate with retention of configuration at phosphorus, followed by the attack of nucleophiles from the backside of Cl to give the substitution products with inversion of configuration at the phosphorus center. A plausible mechanism was proposed for these reactions.
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