Systematic Review of the Epidemiology, disease severity and preventive measures of Mpox disease: A public health guideline for densely-populated countries

Abstract

Background Research on Mpox is essential to protect public health, develop effective interventions, and enhance global preparedness for infectious disease outbreaks. Owing to the scarcity of any specific treatment for Mpox disease, public health guidelines are important for patient care and management. Therefore, this systematic review suggests a public health policy guidelines to control Mpox diseases, especially in densely populated countries. Methods In this systematic review study, the databases and search engines PubMed, Scopus, BanglaJol, WHO, and Google Scholar were searched, and related literature was retrieved for further investigation. Articles describing monkeypox epidemiology, clinical symptoms, and preventive strategies, and published in English language were the core inclusion criteria; articles published in other languages were excluded. All records in the literature were managed through Mendeley (version 1.19.4) reference manager and summarized for further investigation. Results Mpox severity is prevalent in America and Europe. Male (96.3%) and young adults aged 18-44 years (mean: 34 years) were the most vulnerable population due to the virus. Among the patients, rash and fever were the most frequent symptoms, with cough, vomiting, anogenital pain and/or bleeding, conjunctivitis, diarrhea, and genital edema being the least prevalent symptoms in less than 5% of the patients. As there is no specific treatment for the disease, infection control in densely populated countries require early detection, isolation of infected individuals, strict infection control measures, mass vaccination campaigns, education, public awareness campaigns, and continued investment in research. Conclusions This study underscores the urgent need for comprehensive infection control strategies, including early detection, strict isolation protocols, mass vaccination initiatives, and ongoing research investment given the absence of specific treatment options for the disease.