Abstract
Since its birth, systems biology has gained a great deal from the protocols devised to study phenomena at the level of single proteins and nucleic acids. Such protocols find broad markets and utility at higher levels of biological organization, from next-generation sequencing, which uses modified nucloeotides and fluorescent identifiers (1), to ChIP-seq analysis, which identifies histone modifications and binding sites in protein–DNA interactions (2). In PNAS, Sivaramakrishnan and Spudich introduce a system for interrogating interactions between pairs of proteins, domains, and peptides (3), and it is very possible that their invention will find applicability in the construction and analysis of large-scale protein–protein interaction networks (4).
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