Abstract
In this study, process integration for crystallization of a priori purified Artemisia annua L. is investigated. For this total process, the integration operation boundaries and behavior of the crystals are studied. This is performed focusing on a conceptual process design study for artemisinin, aiming towards the development of a crystallization step under given parameters by process integration. At first, different crystallization systems consisting of ethanol-water or acetone-water mixtures are compared. In subsequent steps, the metastable zone width and the behavior of the crystals regarding agglomeration and breakage are checked. Furthermore, the sensitivities of process variables based on several process parameters are investigated. Additionally, the final process integration of crystallization as a combined purification and isolation step is studied.
Highlights
Purified substances from natural sources are used to treat various diseases
Addition, sensitivities of different product quality and their investigated at pilot scale
It is demonstrated that the detected metastable zone width is influenced by influences are investigated at pilot scale
Summary
Purified substances from natural sources are used to treat various diseases. To obtain pure substances from plant material, several process steps are necessary. A typical process may include extraction as a capture step, followed by purification steps such as liquid-liquid extraction, chromatography and crystallization [3,4,5,6]. The whole study includes a detailed investigation of each process step, a conceptual process design and cost estimation. These aspects are divided into the following five articles: Part 0: Sixt, M.; Strube, J. Systematic and model-assisted evaluation of solvent based- for pressurized hot water extraction for the extraction of Artemisinin from Artemisia annua L. Processes 2017, 5, 86, doi:10.3390/pr5040086 [7]
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