Abstract
Perinatal hypoxic-ischemic encephalopathy (HIE) can result in newborn death or long-term neurologic injury. Hypothermia (HPT) reduces mortality and developmental complications from HIE, but 40-50% of infants still die or suffer severe disability. Given synthetic PreImplantation Factor’s (sPIF) neuroprotective effects, we examined the efficacy of sPIF against HIE alone or with HPT.
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