Abstract
Synthesis, structure and antimicrobial evaluation of new derivatives of theophylline sugar hydrazones
Highlights
Theophylline derivatives in 7- and 8-positions have been investigated in the respect of their bronchospasmolytic[1,2,3,4] anticancer[5] and circulatory blood system activity.[6]
Our goal was the synthesis of [1,2,4]triazolo[4,3-e]theophylline derivatives as new acyclo C-nucleosides via theophylline sugar hydrazones and to explore the biological activities of the products
We report here the synthesis, structure and antimicrobial activity of new theophylline sugar hydrazones
Summary
Theophylline derivatives in 7- and 8-positions have been investigated in the respect of their bronchospasmolytic[1,2,3,4] anticancer[5] and circulatory blood system activity.[6]. Acyclo C-nucleosides represent an important class of compounds characterized by an acyclic sugar moiety attached to the heterocycle through a carbon-carbon bond. Acyclonucleosides have been recently classified according to the type of glycon rather than the aglycon part They differ from parent ribonucleosides only by the absence of the ring structure of the pentosyl residue due to the absence of one or more of the bonds of the pentose moiety to give an open-chain residue.[19,20,21,22,23] They have been reported to have valuable biological activities.[19,20,21,22,23] Sugar hydrazones of theophyllin-7-ylacetic acid were reported by Klosa24a in 1958 and some of other reported sugar hydrazones have been found to possess antitumor, antibacterial and antiviral activities.24b
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