Abstract
A potential metal-based chemotherapeutic product based on a benzothiazole Schiff base and first-row transition metals was synthesizedand illustrated analytically and spectrally to investigate the biochemical priority of transition-metal drugs for molecular target DNA.As a result of the magnetic susceptibility data, it was shown that Co (II), Ni (II) and Cu (II) complexes are paramagnetic and have anoctahedral geometry at ambient temperatures. Molar conductivity experiments showed that almost all of the complexes in dimethylformamide were non-electrolytes. This study examined the interactions between CT-DNA and metal (II) complexes. Therefore, thecopper(II) complex significantly improves DNA binding compared to the other complexes. Additionally, this finding was supported bygel electrophoresis, thermal denaturation, and viscosity methods.
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