Abstract
A total of 12 substituted naphthoic acid-linked imidazothiadiazole derivatives were synthesized and evaluated for their anticancer potential against human lung cancer cell line A-549 and also for their antimicrobial activity by measuring zone of inhibition (mm) against S. aureus, B. subtilis and E. coli, respectively. The minimum inhibitory concentration (MIC) value was also determined. The proposed derivatives showed moderate to good antimicrobial activity, especially derivatives C1, C2, C4, C5 and C10, were found to be most active, while other derivatives show minimal activity. Derivatives C1, C3, C4, C5, C10 and C12 showed good to moderate growth inhibition on human lung cancer cell line A-549.
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