Synthesis, Spectral Characterization In Vitro Biological and Pharmacokinetics Studies of Biologically Active Copper and Zinc Metal Chelates with 4-Mercaptoaniline and Nitrite Ion

Abstract

Copper and zinc metal chelates were synthesized with 4-mercaptoaniniline and nitrite ion using microwave irradiation which is one of the eco-friendly techniques with less reaction time high yield, no hazardous waste, and economic. The prepared metal chelates were structurally characterized based on microanalysis, metal estimation, conductance, nuclear magnetic resonance, electronic spectra, IR and Far-IR, EPR, and powder X-ray diffraction studies. Mononuclear tetragonal geometry of copper complex and square planar geometry of Zn(II) complex was confirmed by the microanalysis, metal estimation, and spectral studies. The neutral nature of the complexes was confirmed by the low molar conductance values. The crystal nature of zinc metal chelate was also confirmed by the XRD data. Antibacterial and antifungal activities of the 4-mercaptoaniline and metal chelates were carried out by the Agar disc diffusion method with the bacterial strains Bacillus, Streptococci, Shigella, and fungal strain Candida albicans. The results indicated that the complexes are more potent against bacterial and fungal strains. The pharmacokinetics studies were computed by using Swiss ADME software to predict the lipophilicity, pharmacokinetics, and drug likeliness of the complexes.