Abstract
A series of isoxazole derivatives (2a-i) were synthesized by conventional method using various substituted chlorovinyl benzaldehydes as precursors. Structures of all the synthesized compounds were confirmed by spectroscopic data (1H NMR, FTIR, HRMS). Single crystal X-ray study of four compounds was carried out. Molecular docking study was performed and the compounds were screened for in vitro anticancer activity. The results show that compounds with no substituent or smaller substituents on benzene ring have significant antiproliferative activity against tested cell line i.e. MCF7.
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