Abstract
Some mixed ligand nickel(II) complexes of thenoyltrifluoroacetone (tta-H) with 2,2ꞌ-bipyridine (bipy), 1,10-phenanthroline (phen) and tetramethylethylenediamine (tmen) [Ni(tta)(N-N)(NO3)]; N-N= bipy, phen, or tmen] have been synthesized and characterized by molar conductance measurements, elemental analysis, mass spectrometry, spectral measurements and antimicrobial activities. Attempt to prepare the mixed ligand nickel(II) complexes containing acetylacetone (acacH), benzoylacetone (bzacH), dibenzoylmethane (dbm-H) and thenoyltrifluoroacetone (tta-H) with ethylenediamine associated with NO3 counter ion led to the formation of [Ni(β-diketone)2en]. The β-diketones enolized acting as bidentate ligand, coordinating to the metal with carbonyl and enolic oxygen, ethylenediamine (en) coordinates to the metal using N, N chromophores. The nickel complexes of the type [Ni(tta)(N-N)NO3)] are five-coordinate square pyramidal in geometry while those of the type [Ni(β-diketone)2en] are six-coordinate octahedral geometry. The conductivity measurement in nitromethane revealed that the [Ni(tta)(N-N)NO3)] complexes are non-electrolyte. The complexes were screened for their in-vitro antimicrobial activity against six microorganisms. A comparison of the complexes with gentamicin showed that most of the complexes are resistant to tested organisms except [Ni(tta)2(en)].H2O, [Ni(bzac)2(en)] and [Ni(bta)2(en)] which compared favourably well in Staphylococcus aureus.
Highlights
There has been growing interest in the metal derivatives of β-diketones during the past two decades and a lot of articles have been published on the synthesis of these metal complexes (Ahumada et al, 2018; Omoregie et al, 2017; Omoregie et al, 2016; Omoregie, 2014; Omoregie, 2012; Arpita and Raman, 2010)
Studies revealed that β-diketones were used in the design of many luminescence compounds (Ahumada et al, 2018) and the metal complexes were used to inhibit the growth of K562 cell (Almeida et al, 2015)
The need to synthesize the mixed-ligand complexes in ratio 1 of β-diketone to 1 of 2,2′-bipyridine, 1,10-phenanthroline, ethylenediamine/tetramethylethylenediamine and investigate their antimicrobial activity
Summary
There has been growing interest in the metal derivatives of β-diketones during the past two decades and a lot of articles have been published on the synthesis of these metal complexes (Ahumada et al, 2018; Omoregie et al, 2017; Omoregie et al, 2016; Omoregie, 2014; Omoregie, 2012; Arpita and Raman, 2010). Studies revealed that β-diketones were used in the design of many luminescence compounds (Ahumada et al, 2018) and the metal complexes were used to inhibit the growth of K562 cell (Almeida et al, 2015). Mixed-ligand nickel(II) complexes containing acac and bzac have been synthesized but there is no report on the synthesis and biological activity of the [Ni(tta)(N-N)(NO3)] and ethylenediamine series. The need to synthesize the mixed-ligand complexes in ratio 1 of β-diketone to 1 of 2,2′-bipyridine, 1,10-phenanthroline, ethylenediamine/tetramethylethylenediamine and investigate their antimicrobial activity. In the process of synthesizing these, ratio 2 of β-diketone and 1 of ethylenediamine were formed
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