Abstract
Poly(amidoamine) (PAMAM) dendrimers up to 4th generation are designed and synthesized via a divergent method based on perylene-3,4,9,10-tetracarboxylic diimide (PTCDI) as a luminescent core. Success of syntheses is proved by different analyses such as Fourier-transform infrared (FT-IR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, X-ray diffraction (XRD), and thermogravimetric analysis (TGA). Due to the photo-induced electron transfer (PET), these systems are configured as a “fluorophore-spacer-receptor”. Results showed that PTCDI-cored dendrimers had semi-crystalline structure with appropriate thermal stability. UV–Vis-NIR reflectance spectra showed that PTCDI-cored PAMAM dendrimers were generation-dependent NIR adsorbent or transparent in the NIR region. MTT assay against SH-SY5Y cells showed that PG4.0 was rather cytocompatible and solubility, compatibility, and fluorescent properties of core were improved by generation progression of dendrimers. Finally, SH-SY5Y cells were used to measure cell uptake and fluorescence imaging performances of PG4.0 pigment which showed a good ability to live-cell fluorescence imaging.
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