Abstract
Abstract Catalytic efficiency in synthesis of vitamin E succinate was dramatically increased via the preparation of robust catalyst and the improvement of reaction system. 4-dimethylaminopyridine (DMAP) was covalently immobilized on nano-SiO2 to avoid the catalyst contamination of the product and permit the easy recycling of DMAP. Then, a hexane-acetone mixed solvent system was firstly introduced to replace the traditional single-solvent system, which was employed to improve the activity of immobilized DMAP derivative and the substrate solubility of the reaction system. The highest vitamin E succinate yield of 94% was achieved. In addition, the recyclability and stability of the immobilized DMAP derivative was excellent, the yield of vitamin E succinate had no obvious loss and remained 90% after recycling 20 times. The excellent results make this technology be a promising candidate for the industrial production of vitamin E succinate.
Highlights
For nano-SiO2 (NS), γ-chloropropyl-functionalized nano-SiO2 particles (NS-Cl) and nano-SiO2 immobilized DMAP derivative (NS-DMAP), the weight loss from 30 to 200°C was attributed to the desorption of physically absorbed water [25], which could be confirmed by the peak of DTG at 30 to 200°C
DTG showed that the peak at 400 to 600°C only can be observed by NS-Cl and NS-DMAP, the result demonstrated that the CPTMS was successfully coupled on external surface of nano-SiO2
The last weight loss between 200 and 400°C was attributed to the decomposition of DMAP, and the characteristic peak of DTG only can be observed by NS-DMAP [26]
Summary
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