Abstract
Reaction of solid-phase catalytic heterogeneous isotope exchange of 2-deoxy-D-glucose and its derivative, O(6)-(4-bromothiophenyl)guanine-C8-β-D-glucose with tritium has been studied. It was shown that performing the reaction of solid-phase catalytic heterogeneous isotope exchange under comparatively mild conditions at 110–120°C enables synthesis of rather labile tritium-labeled compounds, such as 2-deoxy-D-glucose and O(6)-(4-bromothiophenyl)guanine-C8-β-D-glucose. The molar radioactivities of the compounds obtained were 6.1 and 7.9 Ci/mmol, respectively.
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