Abstract
A series of thiourea derivatives ( 7– 23, 25– 27) of 1-aminotetrahydronaphthalene ( 4) and 1-amino-2-hydroxytetrahydronaphthalene ( 5) were synthesized in single pot in 48–90% yield and evaluated for their anorexigenic activity. Among them compounds 10, 14, 15, 16 and 22 exhibited significant anorexigenic activity without any antidepressant effect and provided a new structural lead for appetite suppressants.
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