Abstract
Various 1-(2,4-dihydroxythiobenzoyl)imidazoles, -imidazolines and -tetrazoles were synthesized and evaluated for their in vitro antifungal activity. Compounds were prepared by the reaction of sulfinyl-bis-(2,4-dihydroxythiobenzoyl) with properly substituted azoles. The MIC values against the Candida albicans ATCC 10231 strain, the azole-resistant clinical isolates of C. albicans and non- Candida species were determined. Tetrazole derivatives were the most active against C. albicans, imidazoline derivatives against non- Candida species. All compounds showed higher activity than that of comparable drugs.
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