Abstract
AbstractThe indole (1) and chroman analogs (2) of mevinolin and their 6S diastereomers 15c and 25d were synthesized in several steps starting with methyl (R)‐3‐[(tert‐butyldimethylsilyl)oxy]‐4‐formylbutyrate (12) and 2‐(indol‐3‐yl)ethanol (3) or 6‐methoxychroman‐4‐one (16), respectively. Compounds 1 and 2 inhibited moderately the HMG‐CoA reductase. The diastereomers 15c and 25d were shown to be inactive.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
