Abstract
In this study, novel caged antisense oligonucleotides with thiochromone S,S-dioxide as the photolabile protecting group were synthesized, and their photodeprotection was investigated. In vitro experiment, the original target molecule was successfully recovered by photoirradiation. Furthermore, the photodeprotection process was also successfully monitored by the fluorescence spectroscopy of highly fluorescent byproducts generated from the thiochromone-type photolabile protecting group.
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