Abstract
The new compounds were synthesized by treating the drug dapsone 1 with chloroacetyl chloride in the presence of base. Both amino groups are acylated to give compound 6. The symmetrical acylated product then treated with Aniline, Saccharine, p-Bromoaniline, m-Bromoaniline, p-Hydroxyaniline, m-Hydroxyaniline, o-Phenylenediamine and m-Phenylenediamine to give compounds 7(a-h). All the new compounds have scanned for their biological activities toward gram negative (Esherichia coli, Proteus mirabilis) and gram positive (Streptococcus pneumoniae, Mycobacterium tuberculosis) bacteria, the synthesized derivatives gave moderate to good activity as compared to the parent drug toward both mentioned types of bacteria.
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