Abstract
Herein we report the obtaining of 1-(3,4-dihydroquinolin-1(2H)-yl)-2- (4-isobutylphenyl)propan-1-one and its characterization. The newly obtained hybrid and its derivatives (hybrids of ibuprofen with 1,2,3,4-tetrahydroisoquinoline, and piperidine) were screened for their in vitro antioxidant, antitryptic, and inhibition of albumin denaturation activity. The lipophilicity was established using both reversed-phase thin layer chromatography and in silico calculations.
Highlights
The obtaining of exactly this hybrid molecule can lead to the biological anti-inflammatory drug, used in the treatment of many musculoskeletal disorders [11], properties of the constituent fragments to be and is the safest traditional choice for utilization during chronic neuroinflammation such combined in the new one
Synthesis we report the successfully 8, as synthesized
1-(3,4-dihydroquinolin-1(2H)-yl)-2-(4-isobutylphenyl)propan-1-one shown in we report the successfully synthesized
Summary
Benzo[b]pyridine or quinoline 1 in Figure 1 is one of the most most prominent prominent organic skeletons itsits interest until nowadays duedue to its skeletons in inmedicinal medicinalchemistry chemistrypractice practiceand andremains remains interest until nowadays to pharmacological properties. its pharmacological properties. Evaluation. 2022, Citation: Manolov, S.; 2022, Ivanov, I.; x. M1350. Accepted:
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