Abstract
Novel racemic polyhydroquinoline derivatives were synthesized by a one-pot approach via a modified Hantzsch reaction and then by aromatization. The optical resolution was carried out by using lipase l-2 in MTBE containing one equivalent of butanol. This method allows the preparation of (+)-7 (>99% ee) and (-)-8 (99% ee) in 50% yield, respectively. The E value is up to 1175.
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