Abstract
Cyclocarbopalladation/cross‐coupling cascade intramolecular Heck–Suzuki–Miyaura reactions is applied for the first time by palladium immobilized on pyridine‐imidazolium ionic liquid supported magnetic iron oxide nanoparticle catalyst (denoted Pd@Py‐IL‐SPION) for the last step to synthesize trisubstituted arylidene–isoquinolinones derivatives having Combretastatin skeleton. The reaction is performedviapropargylamide intermediates prepared by Ugi 4‐CR reactions, which undergoes intramolecular Heck–Suzuki–Miyaura domino reaction to produce the desired trisubstituted arylidene‐isoquinolinones. The method shows full regio‐ and stereoselectivity derives from the particular Pd‐catalyzedsyn‐insertion of triple bond.
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