Abstract
The work was initiated to study hygienic and toxicological indices of a synthetic analogue for the Sitophilus weevil aggregation pheromone. The toxicity testing of 5-hydroxy-4-methyl-3-heptanone demonstrated its extremely low toxicity for the warm-blood animals, as compared to the one of the typical pesticides. The average lethal dose of the product per orally administered to the white mice was established to be 4375.0 mg kg-1 LD16 and LD84 being 2225.0 mg kg-1 and 6550.0 mg kg-1, respectively. The average lethal dose for rabbits was 5900.0 mg kg-1 5-hydroxy-4-methyl-3-heptanone proved to have a mild skin and conjunctival irritant action, and equally mild functional cumulation. As to chronic toxicity, the acceptable daily dose of 4.3 mg/person/d was calculated and scientifically substantiated. The odor threshold was determined at the dose ranging from 0.35 to 0.7 mg l-1 with the practical limit ranging from 0.35 to 1.5 mg l-1, taste sensation threshold was found at the dose ranging from 1.0 to 3.0 mg l-1 with the practical limit ranging from 3.0 to 7.0 mg l-1
Highlights
Production and reduction to practice of novel chemical, physical and biological products for pest management in agriculture are underway worldwide (Bohinc et al, 2020a)
The aggregation pheromone of Sitophilus granarius and Sitophilus oryzae is produced by the insects in the period good to the development of a population, that is, where there is enough food and possibilities for reproduction, as well as appropriate environmental humidity and temperature
Diastereoisomers of 5-hydroxy-4-methyl-3-heptanone were identified as an aggregation pheromone produced by the male rice weevils (Sitophilus oryzae), and the maize weevils (S. zeamais)
Summary
Production and reduction to practice of novel chemical, physical and biological products for pest management in agriculture are underway worldwide (Bohinc et al, 2020a). Search for novel highly efficient methods for pest control is driven by development of pesticide resistance in pest organisms caused by constant use of the products resulting in the uprise of the pesticide-resistant pest insect populations (Petrunya, 2011). To prevent both quantitative and qualitative losses of agricultural products, the integrated pest management consisting of economically and environmentally feasible measures is needed. The fumigation or any other chemical treatment is supposed feasible in terms of grain infestation extent
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