Abstract
Condensation of protected β-benzyl-aspartate 4 with 2-amino-ethanol, subsequent deprotection of the amino function and coupling with N, N′-di-benzyloxycarbonyl-lysine ( 7) afforded the peptidyl alcohol 8. Glycosylation of methyl 3,4,6 tri- O-benzyl-α- d-mannopyranoside ( 11) by ethyl 2,6-di- O-benzoyl-3,4-di- O-benzyl-1-thio-α- d-mannopyranoside ( 14) gave, after debenzoylation and protection of the 2′-hydroxyl function, the suitably protected dimannoside 21. Phosphitylation of 21 with benzyloxy- bis-( N, N-diisopropylamino)phosphine ( 18) followed by the addition of 8 gave, after oxidation and subsequent hydrogenolysis of the benzyl groups, the title compound in a good yield.
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